Biochemical markers for Huntington's chorea.
نویسندگان
چکیده
The uptake of dopamine (DA) by platelet rich plasma was assayed in 11 patients with Huntington's chorea (H.C.). The results confirmed the previous observation that platelets from H.C. patients take up, at equilibrium, more dopamine than do platelets from normal control subjects. The mean difference was 50% higher at DA substrate concentrations of 0.11 mM. However, attempts to confirm the higher Na+ - K+ ATPase activity of erythrocyte ghosts from Huntington's chorea patients were unsuccessful.
منابع مشابه
Biochemical Markers for Huntington's Chorea
The uptake of dopamine (DA) by platelet rich plasma was assayed in II patients with Huntington's chorea (H. C). The results confirmed the previous observation that platelets from H.C. patients take up, at equilibrium, more dopamine than do platelets from normal control subjects. The mean difference was 50% higher at DA substrate concentrations of 0.11 mM. However, attempts to confirm the higher...
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It is now generally accepted that Huntington's chorea is inherited through a single dominant autosomal gene but apart from this little is known of the aetiology. Earlier investigators had implicated endocrine factors (Mulon and Porak, 1912; Bize, 1934) but without very convincing evidence. With the advent ofnew drugs that had profound effects on the nervous system the idea of a neuronal basis f...
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The possibility that Huntington's chorea might be due to a genetically determined biochemical derangement has been raised on a number of occasions. In 1963,Kenyon and Hardy suggested that abnormalities of magnesium metabolism might account for some of the features of Huntington's chorea and in a group of patients investigated the cellular magnesium levels using the Szvenk-Fekete titration metho...
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ورودعنوان ژورنال:
- The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
دوره 7 4 شماره
صفحات -
تاریخ انتشار 1980